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1

Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells

Satta, Alessandro, Mezzanzanica, Delia, Caroli, Francesco, Frigerio, Barbara, Nicola, Massimo Di, Kontermann, Roland E., Iacovelli, Federico, Desideri, Alessandro, Anichini, Andrea, Canevari, Silvana,

Journal:

Year:

2018

Language:

english

File:

PDF, 1.72 MB

english, 2018

2

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Ovarian Tumors of Low Malignant Potential (Borderline Ovarian Tumors)

Harter, Philipp, Gershenson, David, Lhomme, Catherine, Lecuru, Fabrice, Ledermann, Jonathan, Provencher, Diane M., Mezzanzanica, Delia, Quinn, Michael, Maenpaa, Johanna, Kim, Jae-Weon, Mahner, Sven, H

Journal:

International Journal of Gynecological Cancer

Year:

2014

Language:

english

File:

PDF, 100 KB

english, 2014

3

Retargeting of human lymphocytes against human ovarian carcinoma cells by bispecific antibodies: from laboratory to clinic

Delia Mezzanzanica, Silvana Canevari, Maria I. Colnaghi

Journal:

International Journal of Clinical & Laboratory Research

Year:

1992

Language:

english

File:

PDF, 605 KB

english, 1992

4

UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines

Modena, Piergiorgio, Testi, Maria Adele, Facchinetti, Federica, Mezzanzanica, Delia, Radice, Maria Teresa, Pilotti, Silvana, Sozzi, Gabriella

Journal:

Year:

2003

Language:

english

File:

PDF, 400 KB

english, 2003

5

MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer

Sun, Yan, Hu, Limei, Zheng, Hong, Bagnoli, Marina, Guo, Yuhong, Rupaimoole, Rajesha, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Ji, Ping, Chen, Kexin, Sood, Anil K, Mezzanzanica, Delia, Liu

Journal:

The Journal of Pathology

Year:

2015

Language:

english

File:

PDF, 726 KB

english, 2015

6

Characterisation of in vivo ovarian cancer models by quantitative 1H magnetic resonance spectroscopy and diffusion-weighted imaging

Rossella Canese, Maria Elena Pisanu, Delia Mezzanzanica, Alessandro Ricci, Luisa Paris, Marina Bagnoli, Barbara Valeri, Massimo Spada, Massimo Venditti, Albino Cesolini, Andrea Rodomonte, Massimo Gian

Journal:

NMR in Biomedicine

Year:

2012

Language:

english

File:

PDF, 361 KB

english, 2012

7

A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling

Roggiani, Francesca, Riva, Cristina, Raspagliesi, Francesco, Porta, Giovanni, Valli, Roberto, Taramelli, Roberto, Acquati, Francesco, Mezzanzanica, Delia, Tomassetti, Antonella

Journal:

Year:

2019

Language:

english

File:

PDF, 4.73 MB

english, 2019

8

Targeting of T lymphocytes against egf-receptor+ tumor cells by bispecific monoclonal antibodies: Requirement of CD3 molecule cross-linking for t-cell activation

Silvano Ferrini, Anna Cambiaggi, Sabrina Sforzini, Sabrina Marciano, Silvana Canevari, Delia Mezzanzanica, Maria Ines Colnaghi, Carlo Enrico Grossi, Lorenzo Moretta

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 835 KB

english, 1993

9

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

Bagnoli, Marina, Beretta, Giovanni L., Gatti, Laura, Pilotti, Silvana, Alberti, Paola, Tarantino, Eva, Barbareschi, Mattia, Canevari, Silvana, Mezzanzanica, Delia, Perego, Paola

Journal:

BioMed Research International

Year:

2013

Language:

english

File:

PDF, 1.29 MB

english, 2013

10

Human carcinoma cell lines xenografted in athymic mice: biological and antigenic characteristics of an intraabdominal model

Marina Ripamonti, Silvana Canevari, Sylvie Ménard, Delia Mezzanzanica, Silvia Miotti, Rosaria Orlandi, Franco Rilke, Elda Tagliabue, Maria Ines Colnaghi

Journal:

Cancer Immunology, Immunotherapy

Year:

1987

Language:

english

File:

PDF, 1.39 MB

english, 1987

11

Bispecific Antibody Targeted T Cell Therapy of Ovarian Cancer: Clinical Results and Future Directions

CANEVARI, SILVANA, MEZZANZANICA, DELIA, MAZZONI, ALESSANDRA, NEGRI, DONATELLA R.M., RAMAKRISHNA, VENKATESH, BOLHUIS, REINDER L.H., COLNAGHI, MARIA I., BOLIS, GIORGIO

Journal:

Journal of Hematotherapy

Year:

1995

Language:

english

File:

PDF, 2.64 MB

english, 1995

12

Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors

Carbotti, Grazia, Orengo, Anna Maria, Mezzanzanica, Delia, Bagnoli, Marina, Brizzolara, Antonella, Emionite, Laura, Puppo, Andrea, Centurioni, Maria Grazia, Bruzzone, Milena, Marroni, Paola, Rossello,

Journal:

International Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 573 KB

english, 2013

13

Choline Metabolism Alteration: A Focus on Ovarian Cancer

Bagnoli, Marina, Granata, Anna, Nicoletti, Roberta, Krishnamachary, Balaji, Bhujwalla, Zaver M., Canese, Rossella, Podo, Franca, Canevari, Silvana, Iorio, Egidio, Mezzanzanica, Delia

Journal:

Frontiers in Oncology

Year:

2016

Language:

english

File:

PDF, 547 KB

english, 2016

14

Immunoconjugate generation between the ribosome inactivating protein restrictocin and an anti-human breast carcinoma MAB

Rosaria Orlandi, Silvana Canevari, Francisco P. Conde, Flavio Leoni, Delia Mezzanzanica, Marina Ripamonti, Maria I. Colnaghi

Journal:

Cancer Immunology, Immunotherapy

Year:

1988

Language:

english

File:

PDF, 865 KB

english, 1988

15

Production and validation of the pharmacokinetics of a single-chain Fv fragment of the MGR6 antibody for targeting of tumors expressing HER-2

Fabio Turatti, Delia Mezzanzanica, Elena Nardini, Elena Luison, Lorenzo Maffioli, Emilio Bombardieri, Claudia de Lalla, Silvana Canevari, Mariangela Figini

Journal:

Cancer Immunology, Immunotherapy

Year:

2001

Language:

english

File:

PDF, 150 KB

english, 2001

16

Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors

Satta, Alessandro, Mezzanzanica, Delia, Turatti, Fabio, Canevari, Silvana, Figini, Mariangela

Journal:

Future Oncology

Year:

2013

Language:

english

File:

PDF, 1.32 MB

english, 2013

17

Highly efficient redirected anti-tumor activity of human lymphocytes transduced with a completely human chimeric immune receptor

Fabio Turatti, Mariangela Figini, Paola Alberti, Ralph A. Willemsen, Silvana Canevari, Delia Mezzanzanica

Journal:

The Journal of Gene Medicine

Year:

2005

Language:

english

File:

PDF, 373 KB

english, 2005

18

Development of a new vaccine formulation that enhances the immunogenicity of tumor-associated antigen CaMBr1

Maria Elisa Perico, Delia Mezzanzanica, Elena Luison, Paola Alberti, Luigi Panza, Giovanni Russo, Silvana Canevari

Journal:

Cancer Immunology, Immunotherapy

Year:

2000

Language:

english

File:

PDF, 231 KB

english, 2000

19

Ovarian cancer: a molecularly insidious disease

Delia Mezzanzanica

Journal:

Chinese Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 455 KB

english, 2015

20

IL-27 induces the expression of IDO and PD-L1 in human cancer cells

Carbotti, Grazia, Barisione, Gaia, Airoldi, Irma, Mezzanzanica, Delia, Bagnoli, Marina, Ferrero, Simone, Petretto, Andrea, Fabbi, Marina, Ferrini, Silvano

Journal:

Year:

2015

File:

PDF, 3.54 MB

2015

21

Analysis of production, purification, and cytolytic potential of bi-specific antibodies reactive with ovarian-carcinoma-associated antigens and the T-cell antigen CD3

Hedda H. van Ravenswaay Claasen, René J. van de Griend, Delia Mezzanzanica, Reinder L. H. Bolhuis, Sven O. Warnaar, Gert Jan Fleuren

Journal:

International Journal of Cancer

Year:

1993

Language:

english

File:

PDF, 993 KB

english, 1993

22

Aberrant phosphatidylcholine metabolism in human ovarian cancer

Egidio Iorio, Alessandro Ricci, Maria Elena Pisanu, Giancarlo Castellano, Marina Bagnoli, Loris de Cecco, Kristine Glunde, Zaver Bhujwalla, Delia Mezzanzanica, Silvana Canevari, Franca Podo

Journal:

Chemistry and Physics of Lipids

Year:

2010

Language:

english

File:

PDF, 48 KB

english, 2010

23

Anti-CD3/Anti-Epidermal Growth Factor Receptor-Bispecific Antibody Retargeting of Lymphocytes against Human Neoplastic Keratinocytes in an Autologous Organotypic Culture Model

Isabelle Renard, Delia Mezzanzanica, Silvana Canevari, Silvano Ferrini, Jacques Boniver, Philippe Delvenne, Nathalie Jacobs

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 1.23 MB

english, 2002

24

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

Rea, Katia, Roggiani, Francesca, De Cecco, Loris, Raspagliesi, Francesco, Carcangiu, Maria Luisa, Nair-Menon, Joyce, Bagnoli, Marina, Bortolomai, Ileana, Mezzanzanica, Delia, Canevari, Silvana, Kourti

Journal:

Journal of Experimental & Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 4.08 MB

english, 2018

25

Use of combination of monoclonal antibodies directed against three distinct epitopes of a tumor-associated antigen: Analysis of cell binding and internalization

Patrizia Casalini, Delia Mezzanzanica, Silvana Canevari, Gabriella Della Torre, Silvia Miorn, Maria Ines Colnaghi, Siegfried Matzku

Journal:

International Journal of Cancer

Year:

1991

Language:

english

File:

PDF, 759 KB

english, 1991

26

Change in Binding Reactivity of an Anti-Tumor Monoclonal Antibody After the Introduction of 2-Pyridyl Disulphide Groups

ORLANDI, ROSARIA, CANEVARI, SILVANA, LEONI, FLAVIO, MEZZANZANICA, DELIA, RIPAMONTI, MARINA, COLNAGHI, MARIA I.

Journal:

Year:

1986

Language:

english

File:

PDF, 1.50 MB

english, 1986

27

In vivo Magnetic Resonance Metabolic and Morphofunctional Fingerprints in Experimental Models of Human Ovarian Cancer

Canese, Rossella, Mezzanzanica, Delia, Bagnoli, Marina, Indraccolo, Stefano, Canevari, Silvana, Podo, Franca, Iorio, Egidio

Journal:

Frontiers in Oncology

Year:

2016

Language:

english

File:

PDF, 648 KB

english, 2016

28

Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2

Cecco, Loris De, Marchionni, Luigi, Gariboldi, Manuela, Reid, James F, Lagonigro, M Stefania, Caramuta, Stefano, Ferrario, Cristina, Bussani, Erica, Mezzanzanica, Delia, Turatti, Fabio

Journal:

Year:

2004

Language:

english

File:

PDF, 600 KB

english, 2004

29

Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism

Penet, Marie-France, Krishnamachary, Balaji, Wildes, Flonne, Mironchik, Yelena, Mezzanzanica, Delia, Podo, Franca, de Reggi, Max, Gharib, Bouchra, Bhujwalla, Zaver M.

Journal:

Frontiers in Oncology

Year:

2016

Language:

english

File:

PDF, 1.90 MB

english, 2016

30

The Aspergillus toxin restrictocin is a suitable cytotoxic agent for generation of immunoconjugates with monoclonal antibodies directed against human carcinoma cells

Francisco P. CONDE, Rosaria ORLANDI, Silvana CANEVARI, Delia MEZZANZANICA, Marina RIPAMONTI, Saturnino M. MUÑOZ, Pablo JORGE, Maria I. COLNAGHI

Journal:

Year:

1989

Language:

english

File:

PDF, 836 KB

english, 1989

31

Role of microRNAs in ovarian cancer pathogenesis and potential clinical implications

Delia Mezzanzanica, Marina Bagnoli, Loris De Cecco, Barbara Valeri, Silvana Canevari

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2010

Language:

english

File:

PDF, 570 KB

english, 2010

32

Targeting of Anti-Tumor Responses with Bispecific Antibodies

Segal, David M., Qian, Jia-Hua, Mezzanzanica, Delia, Garrido, Maria A., Titus, Julie A., Andrew, Sarah M., George, Andrew J.T., Jost, Carolina R., Perez, Pilar, Wunderlich, John R.

Journal:

Year:

1992

Language:

english

File:

PDF, 1.32 MB

english, 1992

33

Approaches to implement bispecific antibody treatment of ovarian carcinoma

S. Canevari, Delia Mezzanzanica, Alessandra Mazzoni, Donatella R. M. Negri, Mariangela Figini, Venkatesh Ramakrishna, Giorgio Bolis, Maria I. Colnaghi

Journal:

Cancer Immunology, Immunotherapy

Year:

1997

Language:

english

File:

PDF, 159 KB

english, 1997

34

Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer

Marina Bagnoli, Silvana Canevari, Delia Mezzanzanica

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2010

Language:

english

File:

PDF, 394 KB

english, 2010

35

One-Carbon Metabolism: Biological Players in Epithelial Ovarian Cancer

Rizzo, Andrea, Napoli, Alessandra, Roggiani, Francesca, Tomassetti, Antonella, Bagnoli, Marina, Mezzanzanica, Delia

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 921 KB

english, 2018

36

IL-27 induces the expression of IDO and PD-L1 in human cancer cells

Carbotti, Grazia, Barisione, Gaia, Airoldi, Irma, Mezzanzanica, Delia, Bagnoli, Marina, Ferrero, Simone, Petretto, Andrea, Fabbi, Marina, Ferrini, Silvano

Journal:

Year:

2015

Language:

english

File:

PDF, 3.54 MB

english, 2015

37

Expression of interleukin-18 in human ovarian carcinoma and normal ovarian epithelium: Evidence for defective processing in tumor cells

Zhao Yuan Wang, Alessia Gaggero, Anna Rubartelli, Ombretta Rosso, Silvia Miotti, Delia Mezzanzanica, Silvana Canevari, Silvano Ferrini

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 736 KB

english, 2002

38

Efficiency of T cell triggering by anti-CD3 monoclonal antibodies (mAb) with potential usefulness in bispecific mAb generation

Nathalie Jacobs, Alessandra Mazzoni, Delia Mezzanzanica, Donatella R. M. Negri, Olga Valota, Maria I. Colnaghi, Michel P. Moutschen, Jacques Boniver, Silvana Canevari

Journal:

Cancer Immunology, Immunotherapy

Year:

1997

Language:

english

File:

PDF, 421 KB

english, 1997

39

Bispecific antibodies and retargeted cellular cytotoxicity: novel approaches to cancer therapy

John R. Wunderlich, Delia Mezzanzanica, Maria A. Garrido, Donald S. Neblock, Peter E. Daddona, Sarah M. Andrew, Vincent R. Zurawski, Silvana Canevari, Maria I. Colnaghi, David M. Segal

Journal:

International Journal of Clinical & Laboratory Research

Year:

1992

Language:

english

File:

PDF, 461 KB

english, 1992

40

A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing

Gaggero, Alessia, Ambrosis, Alessandro De, Mezzanzanica, Delia, Piazza, Tiziana, Rubartelli, Anna, Figini, Mariangela, Canevari, Silvana, Ferrini, Silvano

Journal:

Year:

2004

Language:

english

File:

PDF, 348 KB

english, 2004

41

Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells

Roggiani, Francesca, Mezzanzanica, Delia, Rea, Katia, Tomassetti, Antonella

Journal:

International Journal of Molecular Sciences

Year:

2016

Language:

english

File:

PDF, 1.45 MB

english, 2016

42

Integration of MRI and MRS approaches to monitor molecular imaging and metabolomic effects of trabectedin on a preclinical ovarian cancer model

Canese, Rossella, Palombelli, Gianmauro, Chirico, Mattea, Sestili, Paola, Bagnoli, Marina, Canevari, Silvana, Mezzanzanica, Delia, Podo, Franca, Iorio, Egidio

Journal:

NMR in Biomedicine

Year:

2018

Language:

english

File:

PDF, 1008 KB

english, 2018

43

ROLE OF CYTOKINES IN CANCER CACHEXIA IN A MURINE MODEL OF INTRACEREBRAL INJECTION OF HUMAN TUMOURS

Donatella R.M. Negri, Delia Mezzanzanica, Silvano Sacco, Massimo Gadina, Fabio Benigni, Laura Cajola, Gaetano Finocchiaro, Pietro Ghezzi, Silvana Canevari

Journal:

Year:

2001

Language:

english

File:

PDF, 545 KB

english, 2001

44

Effect of radiochemical modification on biodistribution of scFvD2B antibody fragment recognising prostate specific membrane antigen

Frigerio, Barbara, Benigni, Fabio, Luison, Elena, Seregni, Ettore, Pascali, Claudio, Fracasso, Giulio, Morlino, Sara, Valdagni, Riccardo, Mezzanzanica, Delia, Canevari, Silvana, Figini, Mariangela

Journal:

Immunology Letters

Year:

2015

Language:

english

File:

PDF, 497 KB

english, 2015

45

Unidirectional potentiation of binding between two anti-FBP MAbs: Evaluation of involved mechanisms

Patrizia Casaline, Delia Mezzanzanica, Olga Valota, Elena Adobati, Antonella Tomassetti, Maria I. Colnaghi, Silvana Canevari

Journal:

Journal of Cellular Biochemistry

Year:

1995

Language:

english

File:

PDF, 867 KB

english, 1995

46

Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer

Titone, Rossella, Morani, Federica, Follo, Carlo, Vidoni, Chiara, Mezzanzanica, Delia, Isidoro, Ciro

Journal:

BioMed Research International

Year:

2014

Language:

english

File:

PDF, 230 KB

english, 2014

47

Anti-ovarian carcinoma anti-T3 heteroconjugates or hybrid antibodies induce tumor cell lysis by cytotoxic T-cells

Sitvana Canevari, Sylvie Ménard, Delia Mezzanzanica, Silvia Mjotti, Screnella M. Pupa, Antonio Lanzavrcchia, Maria I. Colnaghi

Journal:

International Journal of Cancer

Year:

1988

Language:

english

File:

PDF, 320 KB

english, 1988

48

Cytokine Release by Peripheral Blood Lymphocytes Targeted with Bispecific Antibodies, and Its Role in Blocking Tumor Growth

DAVID M. SEGAL, JIA-HUA QIAN, SARAH M. ANDREW, JULIE A. TITUS, DELIA MEZZANZANICA, MARIA A. GARRIDO, JOHN R. WUNDERLICH

Journal:

Annals of the New York Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 639 KB

english, 1991

49

Redirected Activity of Human Antitumor Chimeric Immune Receptors is Governed by Antigen and Receptor Expression Levels and Affinity of Interaction

Turatti, Fabio, Figini, Mariangela, Balladore, Emanuela, Alberti, Paola, Casalini, Patrizia, Marks, James D., Canevari, Silvana, Mezzanzanica, Delia

Journal:

Journal of Immunotherapy

Year:

2007

Language:

english

File:

PDF, 224 KB

english, 2007

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